Vitenskapelige publikasjoner relatert til GENAF:

2025

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk. Choi SH, Jurgens SJ, Xiao L, Hill MC, Haggerty CM, Sveinbjörnsson G, Morrill VN, Marston NA, Weng LC, Pirruccello JP, Arnar DO, Gudbjartsson DF, Mantineo H, Christophersen IE, Tveit A. et al. .PMID: 40050430

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SH, Holm H, Chaffin M, Gudbjartsson D, Hill MC, Aegisdottir H, Albert CM,  Christophersen IE, Tveit A. .PMID: 40050429

2024

Sex differences in early-onset atrial fibrillation in Norwegian primary care: a retrospective national database analysis. Kalstø SM, Nygård S, Ariansen I, Tveit A, Christophersen IE.Open Heart. 2024 Aug 20;11(2):e002695. doi: 10.1136/openhrt-2024-002695.PMID: 39164045

Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation.Vad OB, Angeli E, Liss M, Ahlberg G, Andreasen L, Christophersen IE, et al. JACC Basic Transl Sci. 2024.PMID: 38510713

Genetic testing in early-onset atrial fibrillation. Kany S, Jurgens SJ, Ramo JT, Christophersen IE, Rienstra M, Chung MK, et al. Eur Heart J. 2024.PMID: 39028637

2022

Whole-exome sequencing implicates neuronal calcium channel with familial atrial fibrillation. Vad OB, Yan Y, Denti F, Ahlberg G, Refsgaard L, Bomholtz SH, Santos JL, Rasmussen S, Haunsø S, Svendsen JH, Christophersen IE, Schmitt N, Olesen MS, Bentzen BH. PMID: 35154276

A saturated map of common genetic variants associated with human height. Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, et al. . Nature. 2022.PMID: 36224396

2020

Loss-of-Function Variants in Cytoskeletal Genes Are Associated with Early-Onset Atrial Fibrillation O Bundgaard Vad, C Paludan-Müller, G Ahlberg, SM Kalstø, J Ghouse, L Andreasen, S Haunsø, A Tveit, A Sajadieh, I E Christophersen, Hastrup Svendsen, M Salling Olesen PMID: 32013268

2019

Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early-onset lone atrial fibrillation.
Seifert MB, Olesen MS, Christophersen IE, Nielsen JB, Carlson J, Holmqvist F, Tveit A, Haunsø S, Svendsen JH, Platonov PG. PMID: 31152482

Atrial Fibrillation Genetics Update: Toward Clinical Implementation.
Kalstø SM, Siland JE, Rienstra M, Christophersen IE. PMID: 31552271

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, et al. . BMC Cardiovasc Disord. 2019.PMID: 31664920

2018

Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study.
Ellervik C, Roselli C, Christophersen IE, Alonso A, Pietzner M, Sitlani CM, Trompet S, Arking DE, Geelhoed B, Guo X, Kleber ME, Lin HJ, Lin H, MacFarlane P, Selvin E, Shaffer C, Smith AV, Verweij N, Weiss S, Cappola AR, Dörr M, Gudnason V, Heckbert S, Mooijaart S, März W, Psaty BM, Ridker PM, Roden D, Stott DJ, Völzke H, Benjamin EJ, Delgado G, Ellinor P, Homuth G, Köttgen A, Jukema JW, Lubitz SA, Mora S, Rienstra M, Rotter JI, Shoemaker MB, Sotoodehnia N, Taylor KD, van der Harst P, Albert CM, Chasman DI. PMID: 30673084

Multi-ethnic genome-wide association study for atrial fibrillation.
Roselli C, ……  Christophersen IE ……Tveit A…., Ellinor PT. PMID: 29892015

2017

Large-scale analyses of common and rare variants identify 12 new loci 
associated with atrial fibrillation. Christophersen IE, Benjamin EJ, Tanaka T Lunetta KL, Lubitz SA, Ellinor PT; AFGen Consortium. PMID: 28416818

Multi-ancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Malik R, …, Christophersen IE, …, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STARNET, BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC), METASTROKE Consortium, Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study; MEGASTROKE Consortium. PMID: 29531354

Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT, et al.
PMID: 28416822

Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.
Christophersen IE, Magnani JW, Yin X, Barnard J, Weng LC, Arking DE, et al. PMID: 28794112

Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, et al. PMID: 28613276

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium.
Weng L-C, Lunetta KL, Müller-Nurasyid M, Smith AV, Thériault S, Weeke PE, Barnard J, Bis JC, Lyytikäinen L-P, Kleber ME, Martinsson A, Lin HJ, Rienstra M, Trompet S, Krijthe BP, Dörr M, Klarin D, Chasman DI, Sinner MF, Waldenberger M, Launer LJ, Harris TB, Soliman EZ, Alonso A, Paré G, Teixeira PL, Denny JC, Shoemaker MB, Van Wagoner DR, Smith JD, Psaty BM, Sotoodehnia N, Taylor KD, Kähönen M, Nikus K, Delgado GE, Melander O, Engström G, Yao J, Guo X, Christophersen IE, et al. PMID: 28900195

Electrochemical Investigations on the Inactivation of the [FeFe] Hydrogenase from Desulfovibrio desulfuricans by O(2) or Light under Hydrogen-Producing Conditions Rodriguez-Macia P, Birrell JA, Lubitz W, Rudiger O. . Chempluschem. 2017.PMID: 31961578

2016

Whole Exome Sequencing in Atrial Fibrillation. Lubitz SA, Brody JA, Bihlmeyer NA, Roselli C, Weng LC, Christophersen IE, et al. PLoS Genet. 2016.PMID: 27589061

2014

Brugada syndrome risk loci seem protective against atrial fibrillation. Andreasen L, Nielsen JB, Darkner S, Christophersen IE, Jabbari J, Refsgaard L, Thiis JJ, Sajadieh A, Tveit A, Haunsø S, Svendsen JH, Schmitt N, Olesen MS. PMID: 24667784

2013

Rare variants in GJA5 are associated with early-onset lone atrial fibrillation. Christophersen IE¹, Holmegard HN, Jabbari J, Sajadieh A, Haunsø S, Tveit A, Svendsen JH, Olesen MS. PMID: 23040431

Genetic variation in KCNA5: impact on the atrial specific potassium current IKur in patients with lone atrial fibrillation. Christophersen IE¹, Olesen MS, Liang B, Andersen MN, Larsen AP, Nielsen JB, Haunsø S, Olesen SP, Tveit A, Svendsen JH, Schmitt N. PMID: 23264583

Genetic modifier of the QTc interval associated with early-onset atrial fibrillation. Andreasen L¹, Nielsen JB, Christophersen IE, Holst AG, Sajadieh A, Tveit A, Haunsø S, Svendsen JH, Schmitt N, Olesen MS. PMID: 24074973